What 5-year-old brain organoids can teach us

What 5-year-old brain organoids can teach us. Email Bluesky Facebook LinkedIn Reddit Whatsapp X Save article View saved research Three-dimensional, lab-grown brain organoids hold promise for the study of brain development and maturation. Brain development occurs at a slower pace in humans than in most other species, which makes in vitro study particularly challenging.

Previous efforts largely mimicked early stages of brain development and lacked cell-type-specific profiling of organoids. Access options Access through your institution Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Learn more 00 per year only $21.58 per issue Learn more Rent or buy this article Prices vary by article type from $1.95 to $39.95 Learn more Prices may be subject to local taxes which are calculated during checkout doi: https://doi.org/10.1038/d41591-026-00044-0 Related Articles Induced pluripotent stem cells from discovery to translation A roadmap to competitive preclinical packages Oligodendrocyte dysfunction in human age-related cognitive decline. Researchers are dubious News Q&A 28 AUG 26 Endocannabinoids facilitate reward engagement through retrograde gain control Article 26 AUG 26 Granule cells reorient cortical trajectories to separate contexts Article 26 AUG 26 The brain struggles to make new neurons in people with depression News 25 AUG 26 Psychedelics tune the brain to the environment News & Views 19 AUG 26 Human organoids that mimic brain development grown for years in lab News 19 AUG 26 Jobs Faculty Position in Neuroscience – University of Colorado Anschutz Medical Campus (Pharmacology) Assistant or Associate Professor faculty position in the Department of Pharmacology at University of Colorado School of Medicine in Neuroscience.

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Ancient fossils suggest insects conquered land through a long amphibious phase rather than making an abrupt jump from water to dry ground. A newly identified 324-million-year-old species still carried paddle-like abdominal limbs, revealing an evolutionary bridge between aquatic ancestors and modern six-legged insects.

324-million-year-old fossil reveals how insects conquered land. As organisms expanded beyond the oceans, terrestrial environments became home to increasingly diverse communities.

Insects, which today make up the most species-rich animal group on Earth, eventually became central to these ecosystems. Yet important parts of their early transition from water to land have remained unclear.

An international team of researchers has now identified a stem group insect from the Late Mississippian period, about 324 million years ago. By studying this fossil alongside other puzzling specimens from much earlier and later periods, the researchers reconstructed a critical stage in early insect evolution.

Their findings suggest that insects did not become fully terrestrial immediately after beginning to colonize land.

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