Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study

Non-linear associations of plasma 25-hydroxyvitamin D with serum homocysteine and hyperhomocysteinemia in Chinese adults: a cross-sectional study. Download PDF Abstract Plasma 25-hydroxyvitamin D [25(OH)D] deficiency and elevated homocysteine (Hcy) levels are both well-established risk factors for cardiovascular disease (CVD). The relationship between 25(OH)D and Hcy remains unclear.

This study aimed to investigate the associations between plasma 25(OH)D concentrations and serum Hcy levels, as well as the odds of hyperhomocysteinemia (HHcy), in Chinese adults. Based on baseline data from the China Precision Nutrition and Health KAP Real-World Study, this cross-sectional study used multivariable linear and logistic regression models to evaluate the associations of plasma 25(OH)D concentrations with serum Hcy and HHcy, respectively. Restricted cubic spline analyses were performed to evaluate nonlinear dose-response relationships.

HHcy was primarily defined as serum Hcy ≥ 10 µmol/L, and sensitivity analyses were conducted using the conventional threshold of ≥ 15 µmol/L. After multivariable adjustment, plasma 25(OH)D concentrations showed a nonlinear association with serum Hcy. Compared with participants in Q4 (24.3–28.2 ng/mL), those in Q1-Q3 and Q5 had serum Hcy concentrations that were each 0.16 µmol/L higher.

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