Functional FOXA2 3’UTR variant rs1055080 is associated with HBV-related hepatocellular carcinoma risk and postoperative prognosis

Functional FOXA2 3’UTR variant rs1055080 is associated with HBV-related hepatocellular carcinoma risk and postoperative prognosis. Download PDF Abstract Hepatocarcinogenesis is predominantly driven by chronic hepatitis B virus (HBV) infection. Although the transcription factor FOXA2 is known to regulate hepatic development and metabolism, the impact of its genetic predisposition on HBV-related hepatocellular carcinoma (HBV-HCC) remains unclear.

We performed a case-control analysis in 4,921 Chinese participants. Two candidate functional single nucleotide polymorphisms (SNPs) (rs1209523 at the promoter region and rs1055080 at the 3’UTR region) in FOXA2 were genotyped. The functions of FOXA2 SNPs were evaluated by dual-luciferase reporter assays.

The prognostic values of FOXA2 SNPs were evaluated in a postoperative cohort study of 367 patients with HBV-HCC. The frequency of the rs1055080-T allele was significantly associated with reduced risk of HBV-HCC. This association was evident when HBV-HCC patients were compared with asymptomatic HBV carriers and patients with chronic hepatitis B.

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