Association between the prognostic nutritional index and 28-day mortality in patients with sepsis-associated liver injury: a retrospective cohort study

Association between the prognostic nutritional index and 28-day mortality in patients with sepsis-associated liver injury: a retrospective cohort study. Download PDF Abstract The mortality rates of patients admitted to intensive care units (ICUs) with sepsis-associated liver injury (SALI) are relatively high; early identification of SALI patients with poor prognosis is necessary. The Prognostic Nutritional Index (PNI) is associated with the mortality rate in conditions such as cancer, cardiovascular disease, and sepsis.

The correlation between the PNI and mortality rate of patients with SALI remains unclear. Therefore, this study aimed to elucidate the association between the PNI and 28-day mortality in patients with SALI. The admission data of patients diagnosed with SALI admitted to the ICU from 2008 to 2022 were obtained from the Medical Information Mart for Intensive Care-IV database and retrospectively analyzed.

Multivariate Cox regression analysis was used to determine the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). To further validate our findings, we employed a restricted cubic spline (RCS) model, survival curve analysis, receiver operating characteristic (ROC) analysis, and subgroup analysis. This study included 375 patients diagnosed with SALI.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.