Scientists find how “zombie” cells fuel inflammation as we age

Scientists discovered that aging cells can use malfunctioning mitochondria to unlock inflammatory genes and keep the immune system stuck in a prolonged state of alert. Blocking one part of this process reduced inflammation and improved healthy aging in mice, suggesting a promising new strategy for fighting age-related decline. Scientists find how “zombie” cells fuel inflammation as we age.

Scientists find how “zombie” cells fuel inflammation as we age Science News from research organizations Scientists find how “zombie” cells fuel inflammation as we age Blocking a mitochondrial trigger of chronic inflammation helped mice age more healthfully. When the body detects an infection or injury, it sends out alarm signals that recruit immune cells and other cells to eliminate the threat and begin repairing damaged tissue. This response is essential, but it is supposed to shut down once the danger has passed.

As people age, however, certain cells accumulate that can keep inflammation active for much longer than necessary. This persistent inflammation has been associated with many diseases that become more common later in life. Researchers at Sanford Burnham Prebys Medical Discovery Institute, Mayo Clinic, and collaborating institutions have now uncovered a previously unknown connection between mitochondria, cell metabolism, and this chronic inflammation.

Their findings, published in Nature, also showed that interfering with part of the process reduced inflammation and supported healthier aging in mice.