Effects of grape seed extract on immune-related gene expression

Effects of grape seed extract on immune-related gene expression, inflammatory biomarkers, disease activity, and quality of life in patients with ulcerative colitis: a randomized, triple-blind, placebo-controlled trial. Download PDF Abstract Grape seed extract (GSE), a polyphenol-rich nutraceutical with antioxidant and anti-inflammatory properties, has shown promising effects in preclinical colitis models; however, clinical evidence in patients with ulcerative colitis (UC) remains limited. This study provides novel clinical evidence in patients with UC.

A total of sixty-six patients were randomly assigned to receive either GSE (600 mg/day) or placebo (600 mg/day) for 12 weeks. Disease activity was assessed using the Simple Clinical Colitis Activity Index Questionnaire (SCCAIQ), and quality of life using the Inflammatory Bowel Disease Questionnaire‐9 (IBDQ-9). Twenty-nine participants per group completed the study.

Serum High-Sensitivity C-reactive Protein (hs-CRP) decreased significantly in both groups, with a greater reduction in the GSE group compared with placebo at study end (between-group P = 0.002; change P = 0.018). SCCAIQ scores decreased significantly within the GSE group ( P = 0.023), with no significant between-group difference.

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