Sex differences in the associations of body composition and PPARGC1A genetic variants with elevated pulse pressure

Sex differences in the associations of body composition and PPARGC1A genetic variants with elevated pulse pressure. Download PDF Abstract Pulse pressure (PP) is a hemodynamic marker for vascular aging. We investigated the sex-specific associations of bioelectrical impedance analysis (BIA)-derived body composition indices and PPARGC1A/VDR variants with elevated PP risk.

This community-based study analyzed 5,829 adults (20–90 years) from the Taiwan Biobank. Sex-stratified multiple linear regression was used to examine body composition indices. Candidate variants were screened by logistic regression and clumping, followed by the construction of a weighted genetic score (WGS).

Machine-learning models and SHAP analysis were applied to evaluate the relative contributions of body composition, biochemical traits, and genetic susceptibility to elevated PP. FFMI was the only body composition index that remained significantly associated with PP in both females (β = 0.20, p < 0.001) and males (β = 0.07, p < 0.05) after multivariable adjustment. Adiposity-related indices (VFATL, BFR, FMI) were significant only in females.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.