TyG-related indices as reliable markers for identifying MASLD-associated metabolic phenotypes in type 2 diabetes. Download PDF Abstract Modified triglyceride-glucose (TyG) indices, incorporating body composition markers are considered effective diagnostic indicators of insulin resistance (IR) and metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to compare the diagnostic utility of TyG combined with obesity indices for MASLD-associated metabolic phenotypes in patients with type 2 diabetes.
A total of 413 patients with type 2 diabetes mellitus (T2DM) were included in this retrospective observational study. Clinical and biochemical parameters, including anthropometric measures, were collected. Receiver operating characteristic (ROC) analysis, logistic regression, and clustered bar charts were used to analyse the relationships between indicators and MASLD-associated metabolic phenotypes.
Among the participants, 67.6% had MASLD, with a higher prevalence in males (72.8%) than in females (60.3%). The MASLD group exhibited significantly higher levels of waist circumference (WC), body mass index (BMI), abdominal visceral fat (AVF), triglycerides (TG), fasting insulin (FINS), fasting plasma glucose (FPG), homeostatic model assessment of insulin resistance (HOMA-IR), TyG, TyG-WC, TyG-BMI, and TyG-AVF compared with the non-MASLD group. The proportion of MASLD cases increased across higher quartiles of TyG, TyG-WC, TyG-BMI, and TyG-AVF.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
Discover more from ChuckysCarnage
Subscribe to get the latest posts sent to your email.
