Effects of Yijing decoction on diminished ovarian reserve: associations with mitochondrial function, apoptosis, and the PGC-1α/SIRT3/HIF-1α pathway. Download PDF Abstract Diminished ovarian reserve (DOR) is a common reproductive disorder that severely impairs female fertility and lacks effective treatments. Protecting granulosa cells (GCs) has emerged as a promising therapeutic strategy.
Yijing decoction (YJD), a classical Chinese herbal formula, exhibits clinical efficacy against DOR; however, its mechanisms are unclear. This study aimed to evaluate the effects of YJD on ovarian reserve function and explore the potential molecular mechanisms underlying these effects. Ultra-high-performance liquid chromatography-tandem mass spectrometry was used to identify the constituents of YJD and its serum-absorbed prototypes.
Network pharmacology and molecular docking were then performed to predict therapeutic targets and validate component-target interactions. A DOR mouse model was established by intraperitoneal injection of cyclophosphamide, followed by oral administration of YJD or estradiol valerate (positive control) for 8 weeks. Ovarian function was evaluated by estrous cycle monitoring, hormone profiling, and histopathological analysis.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
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