Leukocyte glucose index as an early predictor of composite adverse outcomes in clinically diagnosed acute methanol poisoning: a two-centre retrospective observational study

Leukocyte glucose index as an early predictor of composite adverse outcomes in clinically diagnosed acute methanol poisoning: a two-centre retrospective observational study. Download PDF Abstract Acute methanol poisoning is a life-threatening emergency, and early risk stratification at admission is critical. The leukocyte glucose index (LGI), a marker of systemic inflammation and stress hyperglycaemia, has prognostic value in acute illness but has been studied in only one small methanol cohort.

We evaluated admission LGI in clinically diagnosed acute methanol poisoning at two tertiary emergency departments in Türkiye. We conducted a two-centre retrospective study of adults (≥ 18 years) with clinically diagnosed acute methanol poisoning (compatible history, characteristic features, and high anion-gap metabolic acidosis; serum methanol was not measured) admitted between January 2021 and December 2025. LGI was calculated as (WBC [× 103/µL] × plasma glucose [mg/dL])/1000 from the first admission panel.

The primary outcome was a composite of in-hospital mortality, invasive mechanical ventilation, or haemodialysis; mortality alone was a key secondary outcome. Discrimination was assessed by ROC analysis with paired (DeLong) comparisons, and adjusted associations by logistic regression, including a Firth model containing venous pH, Glasgow coma scale (GCS), and creatinine. Among 83 patients (mean age 40.7 ± 17.4 years; 71.1% male), the composite outcome occurred in 34 (41.0%): mortality 21, intubation 30, and haemodialysis 29.

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