Elevated central sensitization inventory scores are associated with a multidimensional symptom profile after coronavirus disease 2019. Download PDF Abstract Post-COVID-19 condition comprises persistent heterogeneous symptoms, and central sensitization-related manifestations may overlap with neurocognitive, autonomic, affective, and functional complaints. This cross-sectional study examined associations between Central Sensitization Inventory (CSI) scores ≥ 40 and persistent clinical manifestations in 153 adults with symptoms after self-reported COVID-19 who attended an outpatient clinic in southern Brazil during 2021–2022.
Anxiety, depressive symptoms, sleep quality, functional status, and post-COVID-19 symptoms were assessed. Solid Poisson regression estimated prevalence ratios adjusted for age, sex, education, smoking, body mass index, hypertension and diabetes reported after COVID-19, and hospitalization during acute infection. CSI scores ≥ 40 were observed in 56.2% of participants.
In fully adjusted exposure-specific models, elevated CSI scores were associated with brain fog (PR = 1.712; 95% CI 1.185–2.473; p = 0.004), abdominal pain (PR = 1.768; 95% CI 1.206–2.592; p = 0.003), exercise intolerance (PR = 1.533; 95% CI 1.112–2.113; p = 0.009), depressive symptoms (PR = 1.246; 95% CI 1.097–1.416; p = 0.001), and functional limitations (PR = 1.180; 95% CI 1.019–1.368; p = 0.027). Elevated CSI scores were therefore associated with a broad post-COVID-19 symptom profile, although longitudinal studies are needed to clarify temporal direction and determine whether these associations persist across different clinical populations. Explore related subjects Discover the latest articles and news in related subjects.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
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