Association of albumin to neutrophil to lymphocyte ratio with survival cachexia and severe malnutrition in patients with cancer

Association of albumin to neutrophil to lymphocyte ratio with survival cachexia and severe malnutrition in patients with cancer. Download PDF Abstract This study aims to develop and validate a new inflammation-related indicator – the albumin/neutrophil-to-lymphocyte ratio (ANLR) through a multicenter cohort study. The study assesses the prognostic value of this indicator for the overall survival (OS) of cancer patients, as well as its association with severe malnutrition, cachexia, and Karnofsky Performance Status (KPS).

Kaplan–Meier and Cox proportional hazards regression analyses assessed the relationship between ANLR and OS. Restricted cubic spline (RCS) analysis was performed to evaluate nonlinear dose–response associations. Stratified forest plots were used to assess subgroup-specific effects and interaction terms.

Logistic regression was applied to examine the associations of ANLR with cachexia and severe malnutrition. Sensitivity analyses were conducted after excluding patients who died within the early follow-up period. A total of 16,444 patients were randomly assigned to discovery cohort ( n = 11,511) and validation cohort ( n = 4,933).

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