Lipoprotein-related biomarkers HDL-C and apoA-I predict infection risk in patients with liver cirrhosis. Download PDF Abstract Infections are major drivers of decompensation and mortality in cirrhosis. High-density lipoprotein (HDL) and its major protein component apolipoprotein A-I (apoA-I) exhibit immune-modulatory properties, yet their role in predicting infection risk in cirrhosis remains poorly defined.
This single-centre cohort study evaluated baseline HDL cholesterol (HDL-C) and apoA-I in 311 patients with cirrhosis (training: n = 225; temporal validation: n = 86). The primary endpoint was infection requiring antibiotic therapy within 12 months. Cox regression, C-indices and censoring-adjusted time-dependent ROC analyses assessed prognostic performance.
Infections occurred in 24% of the training and 31% of the validation cohort. Lower HDL-C and apoA-I levels were significantly associated with infection risk in both cohorts. In the training cohort, both biomarkers improved discrimination when added to MELD.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
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