Targeting receptor tyrosine kinases: from molecular mechanisms to clinical therapeutics. Targeting receptor tyrosine kinases: from molecular mechanisms to clinical therapeutics | Signal Transduction and Targeted Therapy Thank you for visiting nature.com. You are using a browser version with limited support for CSS.
To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Targeting receptor tyrosine kinases: from molecular mechanisms to clinical therapeutics Download PDF Download PDF Abstract Receptor tyrosine kinases (RTKs), constituting a major family of cell-surface transmembrane receptors, are essential for intracellular tyrosine phosphorylation and signal transduction.
RTK signaling is crucial for cellular fate regulation and tissue homeostasis, and its disruption is linked to many diseases. Herein, we present a comprehensive review of signaling pathways involving RTKs, with a focus on their signal transduction mechanisms and key components, along with their interactions with major signaling cascades such as G protein-coupled receptors, Wnt, and transforming growth factor ฮฒ pathways. We also elucidate the multidimensional roles of RTKs in cancer development and progression, highlighting their key effects on cancer stem cell maintenance, tumor microenvironment modulation, and other factors.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
Discover more from ChuckysCarnage
Subscribe to get the latest posts sent to your email.
