Association of TyG-related indices with cardiometabolic multimorbidity across early cardiovascular-kidney-metabolic syndrome stages 0–3: a prospective cohort study. Download PDF Abstract Cardiovascular–kidney–metabolic (CKM) syndrome is a systemic condition characterized by interrelated cardiac, renal, and metabolic disturbances. The triglyceride–glucose (TyG) index and several of its anthropometry-based derivatives have been increasingly recognized as surrogate markers of insulin resistance and potential predictors of cardiometabolic multimorbidity (CMM).
Whether their predictive performance differs across CKM stages 0–3 remains unclear. This prospective cohort investigation enrolled 646 participants without established CMM at baseline. CKM stages were classified according to AHA criteria based on obesity, metabolic abnormalities, kidney dysfunction, and subclinical cardiovascular disease.
Five surrogate indicators of insulin resistance were examined, including the TyG index and four anthropometry-based TyG-derived indices. To evaluate model discrimination over time, Harrell’s time-dependent C-statistics were calculated. Improvements in predictive performance were further assessed by estimating the net reclassification index (NRI) and the integrated discrimination index (IDI).
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
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