Metaplastic breast carcinoma: a rare breast cancer with distinct biology and therapeutic challenges

Metaplastic breast carcinoma: a rare breast cancer with distinct biology and therapeutic challenges. Download PDF Abstract Metaplastic breast carcinoma (MpBC) is a rare, histologically heterogeneous breast cancer typically treated with regimens developed for triple-negative breast cancer (TNBC), despite distinct biology and insufficient response to standard therapy. MpBC is defined by differentiation of malignant epithelial cells toward non-glandular lineages, reflecting a plasticity that complicates biomarker interpretation and distinguishes it from non-metaplastic TNBC.

In this review, we cover MpBC histopathology, biology, and therapeutic development, calling for dedicated clinical investigation that recognizes MpBC as a biologically distinct entity. Explore related subjects Discover the latest articles and news in related subjects. Biomarkers Cancer Computational biology and bioinformatics Oncology Acknowledgements This work was supported in part by the NCI Cancer Center Support Grant P30CA016672 to The University of Texas MD Anderson Cancer Center and by the State of Texas Rare and Aggressive Breast Cancer Research Program.

Is supported by a training fellowship from the Gulf Coast Consortia, on the Training In Precision Environmental Health Sciences (TPEHS) Program (NIH Grant No. Author information Authors and Affiliations UT MD Anderson UTHealth Houston Graduate School of Biomedical Sciences, Houston, TX, USA Ahmed Shatta Department of Genetics, UT MD Anderson Cancer Center, Houston, TX, USA Ahmed Shatta Department of Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA Diego F. Chamorro Department of Anatomical Pathology, UT MD Anderson Cancer Center, Houston, TX, USA Aysegul Sahin Department of General Oncology, UT MD Anderson Cancer Center, Houston, TX, USA Ajit Bisen Department of Breast Medical Oncology, UT MD Anderson Cancer Center, Houston, TX, USA Ajit Bisen, Inimfon Jackson & Bora Lim Authors Ahmed Shatta View author publications Search author on: PubMed Google Scholar Diego F.

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