Differential associations of baseline

Differential associations of baseline, dynamic change, and cumulative average TyG-BMI with incident cardiometabolic multimorbidity: a longitudinal landmark analysis of CHARLS. Download PDF Abstract Cardiometabolic multimorbidity (CMM) is common, yet the prognostic relevance of temporal triglyceride-glucose body mass index (TyG-BMI) measures remains unclear. A 2015 landmark analysis of the China Health and Retirement Longitudinal Study included 4597 participants.

Baseline TyG-BMI was measured in 2011; dynamic change and cumulative average were derived from 2011 and 2015 measurements. Incident CMM was ascertained during 2015–2020. Discrete-time complementary log–log models estimated associations, with supplementary analyses of the 2015 landmark value, disease transitions, component outcomes, and bootstrap validation.

Baseline and cumulative average TyG-BMI were associated with CMM (HR per 1-SD increase 1.28, 95% CI 1.17–1.40; and 1.25, 95% CI 1.14–1.37, respectively), with linear dose–response patterns. Dynamic change was not independently associated after baseline adjustment (HR 0.96, 95% CI 0.89–1.04). The 2015 landmark value was also associated with CMM (HR 1.19, 95% CI 1.09–1.30), and residualized cumulative average remained associated after accounting for this value (HR 1.17, 95% CI 1.08–1.27).

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