Cumulative proton pump inhibitor exposure and risk of Parkinson’s disease: a nationwide cohort study

Cumulative proton pump inhibitor exposure and risk of Parkinson’s disease: a nationwide cohort study. Download PDF Abstract Using the Korean National Health Insurance Service–National Sample Cohort database, we evaluated the association between proton pump inhibitor (PPI) exposure and the risk of Parkinson’s disease (PD) among adults aged ≥ 40 years with upper gastrointestinal disorders. PPI exposure during the seven years preceding the index date was assessed by overall use, cumulative duration, and cumulative defined daily dose (cDDD).

Inverse probability of treatment weighting (IPTW) and propensity score matching (PSM) were applied, and hazard ratios (HRs) were estimated. Overall PPI use was not significantly associated with PD risk (IPTW HR, 0.95; 95% CI, 0.89–1.02; PSM HR, 0.93; 95% CI, 0.84–1.03). Higher cumulative exposure was associated with elevated risk estimates.

For ≥ 180 days of use, HRs were 2.24 (95% CI, 1.92–2.60) with IPTW and 1.25 (95% CI, 0.91–1.72) with PSM; for ≥ 180 cDDD, the corresponding HRs were 2.20 (95% CI, 1.89–2.57) and 1.32 (95% CI, 1.01–1.null1), respectively. This positive dose-response pattern remained solid across multiple sensitivity analyses, including washout period assessments, although statistical precision varied by matching design. Therefore, these findings suggest a potential association between higher cumulative PPI exposure and an increased risk of PD.

A seven-year study found that people with Parkinson’s disease who were more physically active experienced slower declines in memory, thinking, and movement abilities. Those exercising more than eight hours per week showed almost no average cognitive decline, suggesting that staying active may offer important benefits as the disease progresses.

Scientists discover a surprising double benefit of exercise for Parkinson’s. The findings suggest that staying active could offer two important advantages for people living with Parkinson’s.

Researchers emphasize that the study identified a connection between physical activity and slower symptom progression. It does not establish that exercise directly causes the disease to progress more slowly.

"Parkinson’s disease is a brain disorder that causes movement and cognitive problems that gradually worsen leading to disability and a loss of independence," said study author Dong-Woo Ryu, MD, PhD, of the University of Cincinnati in Ohio. "Previous research has shown associations between physical activity and movement symptoms.

Our study found physical activity may have dual benefits, with associations with slower declines in movement and cognition." Tracking Exercise and Parkinson’s Symptoms Over Seven Years The research involved 294 adults with mild to moderate Parkinson’s disease.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.