Molecular characterization of hepatitis B and hepatitis delta viruses in Mauritanian HBV chronically infected patients. Download PDF Abstract Chronic hepatitis B (CHB) is highly endemic in Mauritania, and co‑infection with hepatitis delta virus (HDV) may worsen liver outcomes. We characterized circulating hepatitis B virus (HBV) and HDV strains and assessed the clinical impact of HDV co‑infection among HBsAg‑positive patients in Nouakchott.
A total of 165 adults with CHB were enrolled at the National Institute of Hepato-Virology. Demographic/clinical data, serological and molecular tests, ultrasound, and fibrosis estimates (APRI, FIB-4) were collected. HBV DNA was quantified by real-time PCR; HDV RNA was measured mainly by RT-ddPCR.
HBV DNA was detectable in 146/165 (88.5%) with median 2197.25 IU/mL; 75/165 (45.45%) exceeded 2000 IU/mL. Total anti-HDV antibodies were found in 68/112 (60.7%) tested; HDV RNA was quantified in 130/165 patients and detected in 34/130 (26.15%) with median 72,271 IU/mL, including 34/68 (50%) of anti-HDV–positive patients. HDV-RNA positivity was associated with symptoms, higher AST/ALT/AFP/APRI/FIB-4, lower HBV DNA detectability, and increased cirrhosis/HCC and treatment use ( p ≤ 0.004).
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
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