Beyond dopamine: the role of non-dopaminergic systems in Parkinson’s disease. Download PDF Abstract Parkinson’s disease (PD) has long been considered a disorder of dopamine depletion. Dopaminergic dysfunction alone cannot explain its clinical complexity.
Emerging evidence implicates non-dopaminergic systems degeneration/dysregulation as critical contributors to PD’s multifaceted pathology. Integrating these systems into a framework of network dysfunction, this review synthesizes current knowledge on the role of non-dopaminergic systems in PD pathogenesis, symptomatology, and therapeutic advancement, advocating for a paradigm shift toward multisystem-targeted therapies. Explore related subjects Discover the latest articles and news in related subjects.
Diseases Movement disorders Neurodegeneration Neurodegenerative diseases Neurological disorders Neuroscience Parkinson’s disease Acknowledgements This work was supported by the National Natural Science Foundation of China (Grant No. Author information Authors and Affiliations Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Lixuan Li & Baorong Zhang Authors Lixuan Li View author publications Search author on: PubMed Google Scholar Baorong Zhang View author publications Search author on: PubMed Google Scholar Corresponding author Correspondence to Baorong Zhang. Ethics declarations Competing interests The authors declare no competing interests.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
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