AI uncovers hidden Ozempic side effects across 400

AI analysis of 400,000 Reddit posts found that users of drugs such as Ozempic, Wegovy, Mounjaro, and Zepbound reported unexpected symptoms including menstrual changes, chills, hot flashes, and fatigue. Researchers cannot say the medications caused these problems, but the patterns may reveal overlooked signals worth studying. AI uncovers hidden Ozempic side effects across 400,000 Reddit posts.

AI uncovers hidden Ozempic side effects across 400,000 Reddit posts Science News from research organizations AI uncovers hidden Ozempic side effects across 400,000 Reddit posts AI analysis of 400,000 Reddit posts uncovered potentially overlooked symptoms reported by users of Ozempic, Wegovy, Mounjaro, and Zepbound. After analyzing more than 400,000 Reddit posts, an University of Pennsylvania team identified several symptoms reported by people using semaglutide (Ozempic, Wegovy, and Rybelsus) and tirzepatide (Mounjaro and Zepbound) that may not be fully represented in clinical trials or official regulatory information. The study, published recently in Nature Health, examined more than five years of posts from nearly 70,000 Reddit users.

Two categories stood out as particularly deserving of further investigation: reproductive symptoms, including changes in menstrual cycles, and problems involving body temperature, such as chills and hot flashes. The findings do not establish that the medications caused these symptoms. Instead, researchers say the massive collection of spontaneous patient reports may reveal signals worth examining more closely.

"Some of the side effects we found, like nausea, are well known, and that shows that the method is picking up a real signal," says Sharath Chandra Guntuku, Research Associate Professor in Computer and Information Science (CIS) at Penn Engineering and the study’s senior author.