Effect of high-intensity interval or continuous moderate exercise on cognition in a mouse model of mild cognitive impairment

Effect of high-intensity interval or continuous moderate exercise on cognition in a mouse model of mild cognitive impairment. Download PDF Abstract Mild cognitive impairment (MCI) is a common prodromal condition of Alzheimer’s disease (AD), and exercise is a promising non-drug intervention. This study compared the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on cognitive function in senescence-accelerated mouse prone 8 (SAMP8) mice with MCI, examining hippocampal synaptic plasticity mechanisms.

Thirty 4-month-old male SAMP8 mice were randomly assigned to control, MICT, and HIIT groups (n=10). Ten age-matched senescence-accelerated mouse resistant 1 (SAMR1) mice served as normal controls. The MICT and HIIT groups completed 8 weeks of treadmill exercise, while controls received only adaptive training.

Novel object recognition (NOR) and Morris water maze (MWM) tests evaluated recognition and spatial memory. Immunohistochemistry (IHC) and Western blotting were used to measure hippocampal synaptic markers (Postsynaptic density protein-95 (PSD95) and synaptophysin (SYN)). Results showed the control group had decreased discrimination indices and longer MWM escape latency, along with reduced hippocampal PSD95 and SYN expression.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.