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Musculoskeletal pain and atrial fibrillation: the Framingham Heart Study

Musculoskeletal pain and atrial fibrillation: the Framingham Heart Study. Download PDF Abstract Given the morbidity and mortality of atrial fibrillation (AF), identifying factors associated with its onset is a priority. Chronic pain affects one-third of Americans and is linked to cardiovascular disease outcomes, including stroke and mortality.

Since there are common pathophysiological mechanisms, including inflammation and oxidative stress, we sought to investigate whether musculoskeletal pain, including widespread pain (WSP), was associated with AF. Participants aged โ‰ฅ 45 years from the Framingham Heart Study (FHS) Original and Offspring cohorts who completed a pain assessment were included. Pain was categorized into three groups: widespread pain (WSP), non-widespread pain (non-WSP), and no pain.

Incident AF was identified using ECGs and medical records. We assessed the relation of pain and risk of incident AF using Fine-Gray subdistribution hazard modeling accounting for competing risk of death. Models were adjusted for potential confounders.

Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.


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