Social support and HRQoL decline in cirrhosis: a 12-month cohort in China. Download PDF Abstract Health-related quality of life (HRQoL) is important in cirrhosis, but which social support domains are associated with clinically meaningful decline and whether associations vary by compensation status remain uncertain. In this 12-month Chinese cohort, adults with hepatologist-confirmed cirrhosis completed the Duke Social Support Index at baseline.
Social Network and Social Interaction were count-based, whereas Subjective and Instrumental Support ranged from 0 to 40 and 0โ52. HRQoL was assessed using the Chronic Liver Disease Questionnaire at baseline and 12 months. The primary outcome was a decrease of at least 0.5 points in mean CLDQ.
Firth logistic regression estimated adjusted associations; compensation-status-stratified and interaction analyses assessed heterogeneity. Solid linear regression examined continuous change. Among 567 participants (72.0% compensated), 111 (19.6%) had MCID-defined decline.
Medical Disclaimer: This article is for informational purposes only and does not constitute medical advice. Always consult with qualified healthcare professionals for medical decisions and treatment options.
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