AI-assisted telerehabilitation in early Parkinson’s disease: a multicenter, randomized, multi-arm comparative trial. Download PDF Abstract This exploratory, multicenter, randomized, rater-blinded, multi-arm comparative trial aimed to evaluate the feasibility and exploratory clinical signals of an AI-facilitated telerehabilitation system across different intervention durations in early-stage Parkinson’s disease (PD). One-hundred and twenty PD patients (Hoehn-Yahr stage ≤2.5) were randomized in a 1:1:1 ratio into short-term (1 month), medium-term (2 months), and long-term (3 months) training groups (15–30 min, 5 days/week).
The primary outcome was the change in MDS-UPDRS Part III score from baseline to 3 months. Secondary outcomes included change in cognition, mood, gait parameters, activity of daily living, and safety. No significant differences were observed between groups for the primary motor outcome at 3 months.
Post hoc responder analysis showed that the 3-month group had higher proportions reaching the exploratory cognitive responder threshold compared with the 1-month group. Exploratory correlations between MoCA changes and motor parameter changes were weak and did not remain statistically significant after false discovery rate correction. No falls or adverse events were recorded throughout the trial.
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