Scientists discover how pancreatic cancer rewrites its DNA to escape treatment

Scientists have discovered how pancreatic cancer cells continually reshape their genetic makeup to become more aggressive, spread, and evade treatment. In laboratory experiments, blocking a key gene reversed some of these dangerous changes, revealing a potential new way to fight the deadly disease. Scientists discover how pancreatic cancer rewrites its DNA to escape treatment.

By examining nearly half a million individual cancer cells, researchers identified genetic changes that could reveal new ways to fight one of the deadliest forms of cancer. The study, conducted by scientists at NYU Langone Health and its Perlmutter Cancer Center, focused on pancreatic ductal adenocarcinoma, a particularly difficult cancer to treat. Nearly 85 percent of patients die within five years of being diagnosed.

Although researchers have already linked more than half a dozen genes to the disease, much remains unknown about how pancreatic cancer develops and adapts. By examining tumor cells individually rather than studying them in large groups, the team gained a clearer understanding of how different populations of cancer cells change their DNA as the disease progresses. How Pancreatic Cancer Evolves To Escape Treatment The researchers discovered that pancreatic tumors contain a variety of distinct cell populations known as clones.