Baseline cognitive impairment predicts cerebrovascular events in stroke-free chinese adults

Baseline cognitive impairment predicts cerebrovascular events in stroke-free chinese adults. Download PDF Abstract Cognitive dysfunction and cerebrovascular diseases are major public health challenges, yet the prognostic role of cognitive impairment before a stroke in populations without stroke history remains unclear. We conducted a community-based longitudinal study on 3,875 Chinese adults aged 40 and older who were free of stroke, assessing their initial cognitive function with the Mini-Mental State Examination (MMSE), where scores less than 24 indicate impairment, and they were followed for 4.1 years.

After adjusting for demographic factors, vascular risks, homocysteine, and intracranial arterial stenosis, Cox proportional hazards models indicated that cognitive impairment independently forecasted the occurrence of ischemic stroke [ adjusted Hazard Ratio ( aHR) = 2.55, 95% Confidence Interval ( CI): 1.33–4.87] and any stroke ( aHR = 2.32, 95% CI:1.24–4.36), but not all-cause mortality ( aHR = 1.79, 95% CI:0.96–3.36). These findings indicate that baseline cognitive impairment in stroke-free adults aged 40 and older is a significant predictor of future cerebrovascular events, emphasizing its importance in early risk assessment and prevention strategies for groups like Chinese adults who have not experienced a stroke. Explore related subjects Discover the latest articles and news in related subjects.

Diseases Neurology Neuroscience Risk factors Abbreviations 95% CI: 95% confidence interval aHR: adjusted hazard ratio APAC: Asymptomatic Polyvascular Abnormalities Community APOE: apolipoprotein E BMI: body mass index CI: cognitive impairment CVD: cardiovascular disease ECAS: extracranial arterial stenosis HDL: high density lipoprotein HR: hazard ratio ICAS: intracranial arterial stenosis IQR: interquartile range LDL: low density lipoprotein MMSE: Mini-Mental State Examination NCI: normal cognition PSCI: post-stroke cognitive impairment TIA: transient ischemic attack BMI: body mass index CI: cognitive impairment Acknowledgements We thank all the study participants, their relatives, the members of the survey teams of the APAC study. Author information Authors and Affiliations Department of Neurology, Kaifeng Central Hospital, No. 85 Hedao Road, Longting District, Kaifeng, 475000, China Zhaobo Shi, Yong Sun & Xinsheng Han Henan Provincial Engineering Technology Research Center for Precision Diagnosis and Treatment of Neuromuscular Diseases, Kaifeng, China Zhaobo Shi, Yong Sun & Xinsheng Han National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Anxin Wang, Xia Meng, Xue Tian, Jing Li & Xiaoli Zhang Epidemiological Research Office, Beijing Neurosurgical Institute, Beijing, China Anxin Wang, Xue Tian, Jing Li & Xiaoli Zhang Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Xia Meng Authors Zhaobo Shi View author publications Search author on: PubMed Google Scholar Anxin Wang View author publications Search author on: PubMed Google Scholar Xia Meng View author publications Search author on: PubMed Google Scholar Xue Tian View author publications Search author on: PubMed Google Scholar Yong Sun View author publications Search author on: PubMed Google Scholar Jing Li View author publications Search author on: PubMed Google Scholar Xiaoli Zhang View author publications Search author on: PubMed Google Scholar Xinsheng Han View author publications Search author on: PubMed Google Scholar Corresponding author Correspondence to Xinsheng Han.

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